Another topic of interest in our lab is the live dynamics of mucus and its response to invading pathogens. Zebrafish appear ideal to study these questions since they secrete mucins prominently in the digestive tract, and their transparency allow visualization of infection and mucus dynamics. In collaboration with Nancy Hopkins at MIT, we are generating animals that secrete fluorescent mucins. With this platform we anticipate to study the live biology and physics of mucus, and also other aspects of mucosal function, for example the interactions between different microbial species or between immune cells and microbes, and the regulation of mucus secretion.